Matrix-Embedded Cytokines to Simulate Osteoarthritis-Like Cartilage Microenvironments
نویسندگان
چکیده
منابع مشابه
Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments.
In vivo, cytokines noncovalently bind to the extracellular matrix (ECM), to facilitate intimate interactions with cellular receptors and potentiate biological activity. Development of a biomaterial that simulates this type of physiological binding and function is an exciting proposition for designing controlled advanced delivery systems for simulating in vivo conditions in vitro. We have decora...
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The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical, biochemical, and genetic factors that contribute to the imbalance in the synthesis and destruction of articular cartilage. It is now well documented that interleukin-1 and tumor necrosis factor-alpha are the predominant proinflammatory and catabolic cytokines involved in disease initiation and progression. Ot...
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We present a novel algorithm combined with computational modeling to simulate the development of knee osteoarthritis. The degeneration algorithm was based on excessive and cumulatively accumulated stresses within knee joint cartilage during physiological gait loading. In the algorithm, the collagen network stiffness of cartilage was reduced iteratively if excessive maximum principal stresses we...
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OBJECTIVE Long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited. The aim of this study was to identify lncRNA expression in articular cartilage and to explore the function of cartilage injury-related lncRNAs (lncRNA-CIR) in OA. METHODS To identify lncRNAs specifically expressed in OA cartilage, we ...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2013
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2012.0385